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Synopsis: One recent study examining Eurasian watermilfoil (Myriophyllum spicatum L., hereafter milfoil) invasions using landscape-level variables found that the amount of forest land cover in the catchment is consistently negatively related to milfoil presence (Buchan and Padilla, 2000). These results suggest that further research is needed to examine the relationships between natural and anthropogenic landscape features and macrophyte cover. The ability of lake and landscape features to predict a variety of macrophyte cover metrics using 54 north temperate lakes were examined. Univariate regression analyses demonstrated that these macrophyte cover metrics are predicted by a wide range of predictor variables, most...