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Imazapic has shown potential to control invasive weeds, such as cheatgrass (Bromus tectorum L.), during ecological restoration, but effects on non-target native plants are poorly known. In a replicated field experiment, as part of restoration for Gunnison sage-grouse (Centrocercus minimus) in Colorado, imazapic was applied in the fall at a high rate (175 g/ha) to control cheatgrass in mowed Wyoming big sagebrush (Artemisia tridentata Nutt. ssp. wyomingensis Beetle & Young). Cheatgrass was reduced, but only by 67%, and non-native forbs were reduced by 80% by the following summer. However, native forbs also declined (by 84%). Two native grasses declined, but others were not affected. Damage to native forbs would likely...