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This dataset provides results for the following: (1) metals concentrations in soils surrounding breeding song bird nest sites; (2) metals concentrations in invertebrates (earthworm and grub composites) collected near nest sites; (3) metals concentrations and delta-aminolevulinic acid dehydratase (ALAD) activity in avian blood samples; and (4) metals concentrations, indicators of oxidative stress and DNA damage, and histopathology in liver and/or kidney tissues collected from breeding song birds.
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These data are comprised of measurements of aluminum, iron, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, silver, cadmium, thallium, lead, bismuth, thorium, uranium, and mercury in invertebrates, vegetation, and small rodents. Gross alpha activity, gross beta activity, and radionuclide activities (isotopic U, isotopic Th) are also presented for vegetation; radioactivities for small rodents were previously presented at https://doi.org/10.5066/P9HARTQ4. Histopathology results are given for liver and kidney lesions generally associated with metals toxicoses in small rodents. Samples were collected at the Pinenut Mine (active mining) and Arizona 1 Mine (post-production) in the Grand Canyon watershed....
Although cyclosporine has high specificity for the immune system, immunosuppressive therapy with CsA is often complicated by nephrotoxicity. The main morphologic targets of CsA nephrotoxicity include the tubular epithelial and endothelial cells. These cells were investigated in vitro. CsA caused a dose- and time-dependent inhibition of cell growth, vacuolization and fatty change in adherent cells, detachment, and cell death. Inhibition of 3H-TdR incorporation in cells of both tubular epithelial and endothelial origin occurred between 3 microM and 10 microM. Electron microscopy studies revealed cellular swelling, dilatation of the endoplasmic reticulum, and the presence of lipid droplets and giant mitochondria. The...


    map background search result map search result map Chemical analyses and histopathology of organisms and plants collected from breccia pipe uranium mine sites in the Grand Canyon watershed, 2015-2020 Breeding songbird tissue analysis and metal concentrations in tissues, soil and invertebrates collected near nesting sites within the Southeast Missouri Lead Mining District, 2016-19 Chemical analyses and histopathology of organisms and plants collected from breccia pipe uranium mine sites in the Grand Canyon watershed, 2015-2020 Breeding songbird tissue analysis and metal concentrations in tissues, soil and invertebrates collected near nesting sites within the Southeast Missouri Lead Mining District, 2016-19