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Alteration of natural flow regimes by river regulation affects fish distribution and assemblage structure, but causative pathways are not always direct and may go unrecognized. The Colorado River population of the endangered Colorado pikeminnow, Ptychocheilus lucius, suffers from low rates of recruitment and reduced carrying capacity. We hypothesized that availability of prey fish for this large-bodied native piscivore may, in part, be limited by reduced standing crops of periphyton and macroinvertebrates resulting from accumulation of fine sediment in the riverbed. We stratified the 373-km-long study area into 11 strata and sampled various physical and biological parameters in runs and riffles of three randomly...