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Laboratory bioassays were conducted between 2014-2016 at Wayne State University in cooperation with USGS to determine if different species of cyanobacteria influence quagga mussel spawning and fertilization success. The data describes the algal cultures tested and their density/concentration, the number of individuals tested, and the spawning and fertilization success of quagga mussels exposed to the cyanobacteria and those that were not (control).