Skip to main content

Monkeypox challenge of rope squirrels: data


Publication Date
Start Date
End Date


Falendysz, E., Lopera, J., and Rocke, T., 2017, Monkeypox challenge of rope squirrels: data: U.S. Geological Survey data release,


Monkeypox virus (MPXV) is a zoonotic disease endemic in Central and West Africa and is the most virulent orthopoxvirus affecting humans since the eradication of variola virus (VARV). In order to assess their reservoir potential, wild-caught rope squirrels were experimentally infected via intranasal and intradermal exposure with a recombinant MPXV strain from Central Africa engineered to express the luciferase gene. After infection, we monitored viral replication via in vivo bioluminescent imaging and viral shedding via culture and PCR. MPXV infection in African rope squirrels caused mortality and moderate to severe morbidity, with clinical signs including pox lesions in the skin, eyes, mouth and nose, dyspnea, and profuse nasal discharge. [...]


Point of Contact :
Tonie E Rocke
Originator :
Elizabeth Falndysz, Juan Lopera, Tonie E Rocke
Metadata Contact :
Tonie E Rocke
Distributor :
U.S. Geological Survey - ScienceBase
USGS Mission Area :
SDC Data Owner :
National Wildlife Health Center

Attached Files

Click on title to download individual files attached to this item.

ELISA data.csv 470 Bytes text/csv
Luminescence data.csv 682 Bytes text/csv
Neutralization data.csv 1.96 KB text/csv
Viral shedding table.csv 2.92 KB text/csv


To assess viral shedding and pathology of monkeypox virus infection in rope squirrels; to help determine their role in monkeypox epidemiology in humans.


Spatial Services

ScienceBase WMS


  • National Wildlife Health Center
  • USGS Data Release Products



Data source
Input directly

Additional Information


Type Scheme Key
DOI doi:10.5066/F7GH9GGM

Item Actions

View Item as ...

Save Item as ...

View Item...