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Predictive framework for estimating exposure of birds to pharmaceuticals

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Bean, T. G., Arnold, K. E., Lane, J. M., Bergström, E., Thomas-Oates, J., Rattner, B. A., and Boxall, A. B. A., 2017, Predictive framework for estimating exposure of birds to pharmaceuticals: Environmental Toxicology and Chemistry, v. 36, no. 9, p. 2335-2344.

Summary

We present and evaluate a framework for estimating concentrations of pharmaceuticals over time in wildlife feeding at wastewater treatment plants (WWTPs). The framework is composed of a series of predictive steps involving the estimation of pharmaceutical concentration in wastewater, accumulation into wildlife food items, and uptake by wildlife with subsequent distribution into, and elimination from, tissues. Because many pharmacokinetic parameters for wildlife are unavailable for the majority of drugs in use, a read-across approach was employed using either rodent or human data on absorption, distribution, metabolism, and excretion. Comparison of the different steps in the framework against experimental data for the scenario where [...]

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Type Scheme Key
local-index unknown 70190392
local-pk unknown 70190392
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.1002/etc.3771
series unknown Environmental Toxicology and Chemistry

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citationTypeArticle
journalEnvironmental Toxicology and Chemistry
languageEnglish
parts
typevolume
value36
typeissue
value9

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