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Exposure of Peromyscus leucopus to lead and cadmium in the Southeast Missouri Lead Mining District


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Beyer, W.N., Gramlich, Eric, and Nichols, John, 2017, Exposure of Peromyscus leucopus to lead and cadmium in the Southeast Missouri Lead Mining District: U.S. Geological Survey data release,


The exposure of white-footed mice (Peromyscus leucopus) to lead and cadmium and the potential associated toxic effects were examined at three sites contaminated with lead in the Southeast Missouri Lead Mining District and at a reference site. Mice from the contaminated sites showed evidence of oxidative stress and red-blood cell δ-aminolevulinic acid dehydratase (ALAD) activity was depressed by an average of 68% at the most contaminated site. However, histological examinations of the liver and kidney, cytologic examination of blood smears and biomarkers of lipid peroxidation and DNA damage failed to show evidence of toxic effects from lead. The biomagnification ratio of cadmium (hepatic concentration/ soil concentration) at a site [...]


Point of Contact :
W. Nelson Beyer
Originator :
W. Nelson Beyer, Gramlich, Eric, Nichols, John
Metadata Contact :
W. Nelson Beyer
Publisher :
U.S. Geological Survey
Distributor :
GS ScienceBase
USGS Mission Area :
Environmental Health
SDC Data Owner :
Eastern Ecological Science Center

Attached Files

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Summary Mice.xlsx 32.62 KB application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
SummaryWorm.xlsx 20.11 KB application/vnd.openxmlformats-officedocument.spreadsheetml.sheet


Mice were collected in Sherman and Longworth live-traps. The chemical analyses of the mice and their interpretation should help risk assessors evaluate hazards of lead and cadmium at contaminated sites.



  • Eastern Ecological Science Center
  • Patuxent Wildlife Research Center
  • USGS Data Release Products



Additional Information


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DOI doi:10.5066/F7JD4V85

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