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Next-generation sequencing reveals cryptic mtDNA diversity of Plasmodium relictum in the Hawaiian Islands

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Next-generation sequencing reveals cryptic mtDNA diversity of Plasmodium relictum in the Hawaiian Islands; 2013; Article; Journal; Parasitology; Jarvi, S. I.; Farias, M. E.; Lapointe, D. A.; Belcaid, M.; Atkinson, C. T.

Summary

Next-generation 454 sequencing techniques were used to re-examine diversity of mitochondrial cytochrome b lineages of avian malaria (Plasmodium relictum) in Hawaii. We document a minimum of 23 variant lineages of the parasite based on single nucleotide transitional changes, in addition to the previously reported single lineage (GRW4). A new, publicly available portal (Integroomer) was developed for initial parsing of 454 datasets. Mean variant prevalence and frequency was higher in low elevation Hawaii Amakihi (Hemignathus virens) with Avipoxvirus-like lesions (P = 0·001), suggesting that the variants may be biologically distinct. By contrast, variant prevalence and frequency did not differ significantly among mid-elevation Apapane [...]

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Type Scheme Key
local-index unknown 70111661
local-pk unknown 70111661
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.1017/S0031182013000905
series unknown Parasitology

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citationTypeArticle
journalParasitology
languageEnglish
parts
typevolume
value140
typeissue
value14

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